Epstaina—Bāras vīruss

Epstaina–Bāras vīruss (EBV), ko sauc arī par cilvēka herpesvīrusu 4 (HHV-4), ir viens no astoņiem zināmajiem herpesvīrusu grupas vīrusiem un viens no visbiežāk sastopamajiem cilvēku vīrusiem. Vīruss nosaukts pēc britu patologa un akadēmiķa Entonija Epstaina (Anthony Epstein, 1921–2024) un īru virusoloģes Ivonas Bāras (Yvonne Barr, 1932–2016), kuri kopīgi šo vīrusu atklāja un informāciju par to publicēja 1964. gadā.

Tas ir visvairāk pazīstams kā infekciozās mononukleozes (dziedzeru drudža) izraisītājs. To arī saista ar vairākām vēža formām, piemēram, Hodžkina limfomu, Bērkita limfomu, kuņģa vēzi, nazofaringālo karcinomu, un simptomiem, kas saistīti ar cilvēka imūndeficīta vīrusu (HIV), piemēram, matu leikoplakija un centrālās nervu sistēmas limfomas.^[1]^[2] Ir pierādīts, ka inficēšanās ar EBV rada lielāku risku saslimt ar noteiktām autoimūnām slimībām,^[3] jo īpaši dermatomiozītu, sistēmisko sarkano vilkēdi, reimatoīdo artrītu, Šēgrēna sindromu,^[4]^[5] un multiplo sklerozi.^[6] Domājams, ik gadu EBV izraisa aptuveni 200 000 vēža gadījumu.^[7]

Atsauces

↑ "Spectrum of Epstein–Barr virus-related diseases: a pictorial review". Jpn J Radiol 27 (1): 4–19. January 2009. doi:10.1007/s11604-008-0291-2. PMID 19373526.
↑ Cherry-Peppers, G; Daniels, CO; Meeks, V; Sanders, CF; Reznik, D (February 2003). "Oral manifestations in the era of HAART.". Journal of the National Medical Association 95 (2 Suppl 2): 21S–32S. PMC 2568277. PMID 12656429.
↑ "Epstein–Barr virus in autoimmune diseases". Best Practice & Research. Clinical Rheumatology 22 (5): 883–96. October 2008. doi:10.1016/j.berh.2008.09.007. PMID 19028369.
↑ Dreyfus DH (December 2011). "Autoimmune disease: A role for new anti-viral therapies?". Autoimmunity Reviews 11 (2): 88–97. doi:10.1016/j.autrev.2011.08.005. PMID 21871974.
↑ Pender MP (2012). "CD8+ T-Cell Deficiency, Epstein–Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis". Autoimmune Diseases 2012: 189096. doi:10.1155/2012/189096. PMC 3270541. PMID 22312480.
↑ "Epstein–Barr virus infection and multiple sclerosis: a review". Journal of Neuroimmune Pharmacology 5 (3): 271–7. September 2010. doi:10.1007/s11481-010-9201-3. PMID 20369303.
↑ http://www.cancerresearchuk.org/about-us/cancer-news/press-release/2014-03-24-developing-a-vaccine-for-the-epstein-barr-virus-could-prevent-up-to-200000-cancers-globally-say

[pmid19373526-1] "Spectrum of Epstein–Barr virus-related diseases: a pictorial review". Jpn J Radiol 27 (1): 4–19. January 2009. doi:10.1007/s11604-008-0291-2. PMID 19373526.

[Cherry-Peppers_2003-2] Cherry-Peppers, G; Daniels, CO; Meeks, V; Sanders, CF; Reznik, D (February 2003). "Oral manifestations in the era of HAART.". Journal of the National Medical Association 95 (2 Suppl 2): 21S–32S. PMC 2568277. PMID 12656429.

[pmid19028369-3] "Epstein–Barr virus in autoimmune diseases". Best Practice & Research. Clinical Rheumatology 22 (5): 883–96. October 2008. doi:10.1016/j.berh.2008.09.007. PMID 19028369.

[pmid21871974-4] Dreyfus DH (December 2011). "Autoimmune disease: A role for new anti-viral therapies?". Autoimmunity Reviews 11 (2): 88–97. doi:10.1016/j.autrev.2011.08.005. PMID 21871974.

[pmid22312480-5] Pender MP (2012). "CD8+ T-Cell Deficiency, Epstein–Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis". Autoimmune Diseases 2012: 189096. doi:10.1155/2012/189096. PMC 3270541. PMID 22312480.

[pmid20369303-6] "Epstein–Barr virus infection and multiple sclerosis: a review". Journal of Neuroimmune Pharmacology 5 (3): 271–7. September 2010. doi:10.1007/s11481-010-9201-3. PMID 20369303.

[7] ttp://www.cancerresearchuk.org/about-us/cancer-news/press-release/2014-03-24-developing-a-vaccine-for-the-epstein-barr-virus-could-prevent-up-to-200000-cancers-globally-say

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